PRECISION ONCOLOGY
Liquid Biopsy (Onco-D-Clare): for Early Cancer Detection
A revolutionary cancer screening blood test to detect cancer based on each person's genetic profile at its earliest stages, even before symptoms appear.
Precision Oncology
Roughly one in five cancers worldwide is linked to an infectious agent — and liquid biopsy can detect circulating tumor cells long before symptoms appear.
PATHOGENESIS
Infectious Pathogens & Carcinogenesis
It is estimated that approximately one in five cancers worldwide is linked to an infectious agent. These pathogens drive malignancy through chronic inflammation, direct genetic damage, and immune suppression.
Oncoviruses
Viruses are the most common pathogenic cause of cancer, accounting for approximately 15% of all human malignancies. They promote oncogenesis through direct genomic integration, chronic inflammation, and immune suppression.
The most prevalent oncovirus globally. Nearly all cervical cancers are HPV-driven; additionally linked to anal, vulvar, vaginal, and oropharyngeal malignancies.
Chronic hepatotropic viruses that cause progressive liver disease, cirrhosis, and hepatocellular carcinoma.
Associated with Burkitt lymphoma, Hodgkin disease, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorders.
Endemic in specific geographic regions; causative agent of adult T-cell leukemia/lymphoma.
Etiologic agent of Kaposi sarcoma and associated lymphoproliferative disorders, particularly in immunocompromised populations.
Clonal integration in merkel cell carcinoma, a rare and aggressive neuroendocrine skin malignancy.
Bacterial Pathogens
While less common than viruses, specific bacterial pathogens are well-established contributors to malignant transformation through chronic inflammation and mutagenic mechanisms.
The primary risk factor in gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Designated a Group 1 carcinogen by the International Agency for Research on Cancer.
Emerging evidence links Salmonella Typhi to cholangiocarcinoma and select E. coli strains to colorectal malignancy through chronic inflammatory pathways.
Parasitic Infections
Certain parasitic helminths cause chronic organ-specific inflammation, establishing a pro-malignant microenvironment characterized by sustained immune activation and epithelial damage.
Endemic in Southeast Asia; chronic bile duct infection drives cholangiocarcinoma through sustained inflammation and direct mutagenic exposure.
Chronic urogenital schistosomiasis is strongly associated with squamous cell carcinoma of the bladder, particularly in endemic African and Middle Eastern regions.
Viral Immunosuppression
Human Immunodeficiency Virus (HIV) and other immunosuppressive pathogens do not directly transform cells, but their dysregulation of immune surveillance permits opportunistic oncoviruses—including KSHV and EBV—to establish persistent infections and drive malignant transformation.
Cancers Detected by Liquid Biopsy
Using a simple blood draw, RGCC’s liquid biopsy uses advanced genomic testing to detect cancer long before symptoms appear or tumors show up on standard imaging scans. Beyond early detection, this technology helps tailor your treatment plan and provides real-time monitoring of your cancer journey."
Solid Tumors
- Breast CancerUsed to monitor treatment response, track metastasis, and assess genetic changes over time.
- Colorectal CancerUsed for both monitoring the disease and screening for early signs of cancer in average-risk adults.
- Prostate, Ovarian & PancreaticParticularly valuable for cancers that are difficult to reach with traditional needle biopsies or lack clear early symptoms.
- Other Solid TumorsAlso shows viability for liver, stomach, esophageal, and bladder cancers.
Blood Cancers
- Leukemia, Lymphoma & MyelomaLiquid biopsy is well-established here, as cancer cells naturally circulate through the blood and bone marrow, making them highly accessible for genetic analysis.
Watch
FAQ